必须声明标量变量 "@Script_ID"。 TLR4/NF-κB信号通路、自噬与炎性痛的关系-《赣南医学院学报》

[1]孙亚兰,黄 诚.TLR4/NF-κB信号通路、自噬与炎性痛的关系[J].赣南医学院学报,2019,39(10):984-988.[doi:10.3969/j.issn.1001-5779.2019.10.003]
 SUN Ya-lan,HUANG Cheng.The relationship between TLR4/NF-κB signaling pathway, autophagy and chronic inflammatory pain[J].,2019,39(10):984-988.[doi:10.3969/j.issn.1001-5779.2019.10.003]





The relationship between TLR4/NF-κB signaling pathway, autophagy and chronic inflammatory pain
孙亚兰1黄 诚23
赣南医学院 1.2018级硕士研究生; 2.基础医学院; 3.疼痛医学研究所,江西 赣州 341000
SUN Ya-lan1 HUANG Cheng23
Gannan Medical University 1.Postgraduate Student of Grade 2018; 2.School of Basic Medicine; 3.Institute of Pain Medicine, Ganzhou, Jiangxi 341000
炎性痛 TLR4 NF-κB信号通路 自噬
Inflammatory pain TLR4 NF-κB signaling pathway Autophagy
The activation of TLR4/NF-κB signaling pathway mainly mediated inflammatory reaction and innate immune response, and plays a critical role in autophagy.Currently, TLR4/NF-κB signaling pathway is with more and more attention in chronic pain, TLR4/NF-κB signaling pathway being activated can mediate and maintain pain hypersensitivity, and participate in the development of chronic inflammatory pain.Studies have shown that the activation of autophagy is involved in modulating inflammatory response.Thus, the role of TLR4/NF-κB signaling pathway in inflammatory pain and autophagy is summarized, which may provide a new theoretical basis for the clinical treatment to inflammatory pain.


[1] Merskey H, Albe Fessard D, Bonica JJ, et al.Pain terms: a list with definitions and notes on usage.Recommended by the IASP subcommittee on taxonomy[J].Pain, 1979, 6(3): 249-252.
[2] Taneja A, Della PO, Danhof M.Challenges in translational drug research in neuropathic and inflammatory pain: the prerequisites for a new paradigm[J].Eur J Clin Pharmacol, 2017, 73(10): 1219-1236.
[3] Liao HY, Hsieh CL, Huang CP, et al.Electroacupuncture attenuates CFA-induced inflammatory pain by suppressing Nav1.8 through S100B,TRPV1, opioid, and adenosine pathways in mice[J].Sci Rep, 2017, 7: 42531.
[4] Weindel CG, Richey LJ, Bolland S, et al.B cell autophagy mediates TLR7-dependent autoimmunity and inflammation[J].Autophagy, 2015, 11(7): 1010-1024.
[5] Moreno-Gonzalo O, Ramirez-Huesca M, Blas-Rus N, et al.HDAC6 controls innate immune and autophagy responses to TLR-mediated signalling by the intracellular bacteria Listeria monocytogenes[J].PLoS Pathog, 2017, 13(12): e1006799.
[6] Anthony NG, Baiget J, Berretta G, et al.Inhibitory Kappa B Kinase alpha(IKKalpha)inhibitors that recapitulate their selectivity in cells against Isoform-Related Biomarkers[J].J Med Chem, 2017, 60(16): 7043-7066.
[7] Kawai T, Akira S.The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors[J].Nat Immunol, 2010, 11(5): 373-384.
[8] Hoffmann A, Leung TH, Baltimore D.Genetic analysis of NF-kappaB/Rel transcription factors defines functional specificities[J].EMBO J, 2003, 22(20): 5530-5539.
[9] Putra AB, Nishi K, Shiraishi R, et al.Jellyfish collagen stimulates production of TNF-alpha and IL-6 by J774.1 cells through activation of NF-kappaB and JNK via TLR4 signaling pathway[J].Mol Immunol, 2014, 58(1): 32-37.
[10] Kuhn H, Petzold K, Hammerschmidt S, et al.Interaction of cyclic mechanical stretch and toll-like receptor 4-mediated innate immunity in rat alveolar type Ⅱ cells[J].Respirology, 2014, 19(1): 67-73.
[11] Kuang X, Huang Y, Gu HF, et al.Effects of intrathecal epigallocatechin gallate, an inhibitor of Toll-like receptor 4, on chronic neuropathic pain in rats[J].Eur J Pharmacol, 2012, 676(1-3): 51-56.
[12] Heiman A, Pallottie A, Heary RF, et al.Toll-like receptors in central nervous system injury and disease: a focus on the spinal cord[J].Brain Behav Immun, 2014, 42: 232-245.
[13] Nicotra L, Loram LC, Watkins LR, et al.Toll-like receptors in chronic pain[J].Exp Neurol, 2012, 234(2): 316-329.
[14] Adegoke EO, Wang C, Machebe NS, et al.Microcystin-leucine arginine(MC-LR)induced inflammatory response in bovine sertoli cell via TLR4/NF-kB signaling pathway[J].Environ Toxicol Pharmacol, 2018, 63: 115-126.
[15] Ruiz-Miyazawa KW, Pinho-Ribeiro FA, Zarpelon AC, et al.Vinpocetine reduces lipopolysaccharide-induced inflammatory pain and neutrophil recruitment in mice by targeting oxidative stress, cytokines and NF-kappaB[J].Chem Biol Interact, 2015, 237: 9-17.
[16] Qian B, Li F, Zhao LX, et al.Ligustilide ameliorates inflammatory pain and inhibits TLR4 upregulation in spinal astrocytes following Complete Freund's Adjuvant peripheral injection[J].Cell Mol Neurobiol, 2016, 36(1): 143-149.
[17] Sun X, Zhang H.miR-451 elevation relieves inflammatory pain by suppressing microglial activation-evoked inflammatory response via targeting TLR4[J].Cell Tissue Res, 2018, 374(3): 487-495.
[18] Li XQ, Zhang ZL, Tan WF, et al.Down-Regulation of CXCL12/CXCR4 expression alleviates ischemia-reperfusion-induced inflammatory pain via inhibiting glial TLR4 activation in the spinal cord[J].PLoS One, 2016, 11(10): e0163807.
[19] Mizushima N, Komatsu M.Autophagy: renovation of cells and tissues[J].Cell, 2011, 147(4): 728-741.
[20] 曹雪涛.免疫学前沿进展[M].第3版.北京: 人民卫生出版社, 2014: 553-554.
[21] KIEFER K, CASAS J, GARCIA-LOPEZ R, et al.Ceramide imbalance and impaired TLR4-mediated autophagy in BMDM of an ORMDL3-overexpressing mouse model[J].Int J Mol Sci, 2019, 20(6):453-458.
[22] Jang HH, Lee KO, Chi YH, et al.Two enzymes in one; two yeast peroxiredoxins display oxidative stress-dependent switching from a peroxidase to a molecular chaperone function[J].Cell,2004,117(5):625-635.
[23] Min Y, Kim MJ, Lee S, et al.Inhibition of TRAF6 ubiquitin-ligase activity by PRDX1 leads to inhibition of NFKB activation and autophagy activation[J].Autophagy, 2018, 14(8): 1347-1358.
[24] Srivastava IN, Shperdheja J, Baybis M, et al.mTOR pathway inhibition prevents neuroinflammation and neuronal death in a mouse model of cerebral palsy[J].Neurobiol Dis, 2016, 85: 144-154.
[25] Qian Y, Commane M, Ninomiya-Tsuji J, et al.IRAK-mediated translocation of TRAF6 and TAB2 in the interleukin-1-induced activation of NFkappa B[J].J Biol Chem, 2001, 276(45): 41661-41667.
[26] SHI CS, KEHRL JH.MyD88 and Trif target Beclin 1 to trigger autophagy in macrophages[J].J Biol Chem, 2008, 283(48): 33175-33182.
[27] SHI CS, KEHRL JH.TRAF6 and A20 regulate lysine 63-linked ubiquitination of Beclin-1 to control TLR4-induced autophagy[J].Sci Signal, 2010, 3(123): a42.
[28] HE Y, SHE H, ZHANG T, et al.p38 MAPK inhibits autophagy and promotes microglial inflammatory responses by phosphorylating ULK1[J].J Cell Biol, 2018, 217(1): 315-328.
[29] FENG Y, GAO J, CUI Y, et al.Neuroprotective effects of resatorvid against traumatic brain injury in rat: involvement of neuronal autophagy and TLR4 signaling pathway[J].Cell Mol Neurobiol, 2017, 37(1): 155-168.
[30] GRACE PM, HUTCHINSON MR, MAIER SF, et al.Pathological pain and the neuroimmune interface[J].Nat Rev Immunol, 2014, 14(4): 217-231.
[31] GAO F, XIANG HC, LI HP, et al.Electroacupuncture inhibits NLRP3 inflammasome activation through CB2 receptors in inflammatory pain[J].Brain Behav Immun, 2018, 67: 91-100.
[32] Hayden MS, Ghosh S.NF-kappaB,the first quarter-century: remarkable progress and outstanding questions[J].Genes Dev, 2012, 26(3): 203-234.
[33] TAKAHAMA M, AKIRA S, SAITOH T.Autophagy limits activation of the inflammasomes[J].Immunol Rev, 2018, 281(1): 62-73.
[34] Sun Q, Fan J, Billiar TR, et al.Inflammasome and autophagy regulation-a two-way street[J].Mol Med, 2017, 23: 188-195.
[35] CADWELL K.Crosstalk between autophagy and inflammatory signalling pathways: balancing defence and homeostasis[J].Nat Rev Immunol, 2016, 16(11): 661-675.
[36] Monkkonen T, Debnath J.Inflammatory signaling cascades and autophagy in cancer[J].Autophagy, 2018, 14(2): 190-198.
[37] Chen B, Huang SG, Ju L, et al.Effect of microRNA-21 on the proliferation of human degenerated nucleus pulposus by targeting programmed cell death 4[J].Braz J Med Biol Res, 2016, 49(6): e5020.
[38] WU J, ZHOU J, CHEN X, et al.Attenuation of LPS-induced inflammation by ICT, a derivate of icariin, via inhibition of the CD14/TLR4 signaling pathway in human monocytes[J].Int Immunopharmacol, 2012, 12(1): 74-79.
[39] HWANG E, LIN P, NGO H, et al.Icariin and icaritin recover UVB-induced photoaging by stimulating Nrf2/ARE and reducing AP-1 and NF-kappaB signaling pathways: a comparative study on UVB-irradiated human keratinocytes[J].Photochem Photobiol Sci, 2018, 17(10): 1396-1408.
[40] 赖丽娟, 刘松, 谢佳丽, 等.三氟淫羊藿素通过抑制氧化应激对脑缺血再灌注损伤的保护作用[J].赣南医学院学报, 2017, 37(3): 343-346.


基金项目:国家自然科学基金项目(31160213); 赣鄱英才555工程领军人才项目; 江西省主要学科学术和技术带头人培养计划项目(20142BCBC22008)
更新日期/Last Update: 2019-11-20