必须声明标量变量 "@Script_ID"。 东莞市某院医院感染病原菌分布情况及耐药性分析-《赣南医学院学报》

[1]张隐妹,林志坚,潘春予.东莞市某院医院感染病原菌分布情况及耐药性分析[J].赣南医学院学报,2019,39(02):153-157.[doi:10.3969/j.issn.1001-5779.2019.02.014]
 ZHANG Yin-mei,LIN Zhi-jian,PAN Chun-yu.Analysis of distribution and drug resistance of nosocomial pathogens in a hospital in Dongguan[J].,2019,39(02):153-157.[doi:10.3969/j.issn.1001-5779.2019.02.014]
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东莞市某院医院感染病原菌分布情况及耐药性分析()
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《赣南医学院学报》[ISSN:1001-5779/CN:36-1154/R]

卷:
39
期数:
2019年02期
页码:
153-157
栏目:
临床研究
出版日期:
2019-02-25

文章信息/Info

Title:
Analysis of distribution and drug resistance of nosocomial pathogens in a hospital in Dongguan
文章编号:
1001-5779(2019)02-0153-05
作者:
张隐妹林志坚潘春予
东莞市第三人民医院,广东 东莞 523326
Author(s):
ZHANG Yin-mei LIN Zhi-jian PAN Chun-yu
Dongguan Third People's Hospital, Dongguan, Guangdong 523326
关键词:
医院感染 病原菌 分布 耐药性
Keywords:
nosocomial infection pathogen distribution drug resistance
分类号:
R197.323.4
DOI:
10.3969/j.issn.1001-5779.2019.02.014
文献标志码:
A
摘要:
目的:探讨医院感染病原菌的分布、耐药情况,为临床合理使用抗菌药物提供依据。方法:回顾性分析某院2016年1月~2017年12月分离的591株医院感染病原菌分布、标本种类及耐药性情况。结果:该院2016年1月~2017年12月医院感染病原菌大多来源于伤口分泌物,其余依次是尿液、痰、全血等。分离的医院感染病原菌主要是革兰阴性菌(77.16%),革兰阳性菌(18.61%),真菌(4.23%)。革兰阴性菌对哌拉西林/他唑巴坦和碳青霉烯类较为敏感(>90%),其他抗菌药物则出现不同程度耐药,尤其是青霉素类耐药(>90%)。革兰阳性菌未出现耐万古霉素、替加环素及利奈唑胺的菌株; 真菌对氟康唑、伏立康唑、伊曲康唑、两性霉素、氟胞嘧啶均敏感,暂未发现耐药菌株。结论:伤口分泌物标本为该院医院感染病原菌分离的主要标本; 革兰阴性菌为主要病原菌,大肠埃希菌是医院感染的主要病原菌; 不同病原菌出现耐药甚至多重耐药、泛耐药和全耐药,临床治疗要加强细菌耐药性检测,根据药敏试验结果合理使用抗菌药物,减少耐药菌株的产生,防止医院感染的发生。
Abstract:
Objective: To investigate the distribution and drug resistance of nosocomial pathogens, and to provide evidence for the rational use of antibiotics. Methods: A retrospective analysis of the distribution, specimen types and drug resistance of 591 nosocomial pathogens isolated from January 2016 to December 2017 was conducted. Results: The pathogens of nosocomial infections in our hospital from January 2016 to December 2017 were mostly derived from wound secretions, followed by urine, sputum and whole blood. The isolated nosocomial pathogens were mainly Gram-negative bacteria(77.16%), Gram-positive bacteria(18.61%), and fungi(4.23%). Gram-negative bacteria are more sensitive to piperacillin/tazobactam and carbapenems(>90%), and other antibiotics have different degrees of resistance, especially penicillin resistance(>90%). Gram-positive bacteria did not show vancomycin-resistant, tigecycline and linezolid-resistant strains; fungi were sensitive to fluconazole, voriconazole, itraconazole, amphotericin, and flucytosine, and no drug resistance was found. Conclusions: The specimens of wound secretion are the main specimens for the isolation of nosocomial pathogens; Gram-negative bacteria are the main pathogens, and Escherichia coli is the main pathogen of nosocomial infection; different pathogens are resistant or even multi-drug resistant, pan-resistant and fully resistant. Drugs, clinical treatment should strengthen the detection of bacterial resistance, rational use of antibacterial drugs according to the results of drug susceptibility test, reduce the emergence of drug-resistant strains, prevent the occurrence of nosocomial infections.

参考文献/References:

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备注/Memo

备注/Memo:
作者简介:张隐妹,女,本科,主管医师,研究方向:医院感染管理。Email:zhym4320@163.com
更新日期/Last Update: 2019-04-08