必须声明标量变量 "@Script_ID"。 TLR4/NF-κB信号通路、自噬与炎性痛的关系-《赣南医学院学报》

[1]孙亚兰,黄 诚.TLR4/NF-κB信号通路、自噬与炎性痛的关系[J].赣南医学院学报,2019,39(10):984-988.[doi:10.3969/j.issn.1001-5779.2019.10.003]
 SUN Ya-lan,HUANG Cheng.The relationship between TLR4/NF-κB signaling pathway, autophagy and chronic inflammatory pain[J].,2019,39(10):984-988.[doi:10.3969/j.issn.1001-5779.2019.10.003]
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TLR4/NF-κB信号通路、自噬与炎性痛的关系()
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《赣南医学院学报》[ISSN:1001-5779/CN:36-1154/R]

卷:
39
期数:
2019年10期
页码:
984-988
栏目:
炎症与免疫·基础与临床
出版日期:
2019-11-24

文章信息/Info

Title:
The relationship between TLR4/NF-κB signaling pathway, autophagy and chronic inflammatory pain
文章编号:
1001-5779(2019)10-0984-05
作者:
孙亚兰1黄 诚23
赣南医学院 1.2018级硕士研究生; 2.基础医学院; 3.疼痛医学研究所,江西 赣州 341000
Author(s):
SUN Ya-lan1 HUANG Cheng23
Gannan Medical University 1.Postgraduate Student of Grade 2018; 2.School of Basic Medicine; 3.Institute of Pain Medicine, Ganzhou, Jiangxi 341000
关键词:
炎性痛 TLR4 NF-κB信号通路 自噬
Keywords:
Inflammatory pain TLR4 NF-κB signaling pathway Autophagy
分类号:
Q422
DOI:
10.3969/j.issn.1001-5779.2019.10.003
文献标志码:
A
摘要:
TLR4/NF-κB信号通路主要介导先天性免疫和炎症反应,在自噬中也发挥重要作用。目前,TLR4/NF-κB信号通路在慢性痛的研究越来越受关注。激活的TLR4/NF-κB信号通路可介导和维持痛敏反应,并参与慢性炎性痛的发生、发展过程。有研究表明自噬参与了炎症反应的调节作用。为此,本文对TLR4/NF-κB信号通路、自噬与炎性痛的关系进行综述,为炎性痛的临床治疗提供新的理论依据。
Abstract:
The activation of TLR4/NF-κB signaling pathway mainly mediated inflammatory reaction and innate immune response, and plays a critical role in autophagy.Currently, TLR4/NF-κB signaling pathway is with more and more attention in chronic pain, TLR4/NF-κB signaling pathway being activated can mediate and maintain pain hypersensitivity, and participate in the development of chronic inflammatory pain.Studies have shown that the activation of autophagy is involved in modulating inflammatory response.Thus, the role of TLR4/NF-κB signaling pathway in inflammatory pain and autophagy is summarized, which may provide a new theoretical basis for the clinical treatment to inflammatory pain.

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金项目(31160213); 赣鄱英才555工程领军人才项目; 江西省主要学科学术和技术带头人培养计划项目(20142BCBC22008)
通信作者:黄诚,男,博士,教授,硕士生导师,研究方向:电针镇痛及慢性痛研究。E-mail:huangc6a2013@163.com
更新日期/Last Update: 2019-11-20