必须声明标量变量 "@Script_ID"。 帕金森病模型的研究现状-《赣南医学院学报》

[1]余子云,游 静,汤坤鑫,等.帕金森病模型的研究现状[J].赣南医学院学报,2019,39(12):1258-1261.[doi:10.3969/j.issn.1001-5779.2019.12.018]
 YU Zi-yun,YOU Jing,TANG Kun-xin,et al.Current status of Parkinson's disease models[J].,2019,39(12):1258-1261.[doi:10.3969/j.issn.1001-5779.2019.12.018]
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帕金森病模型的研究现状()
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《赣南医学院学报》[ISSN:1001-5779/CN:36-1154/R]

卷:
39
期数:
2019年12期
页码:
1258-1261
栏目:
综述
出版日期:
2019-12-31

文章信息/Info

Title:
Current status of Parkinson's disease models
文章编号:
1001-5779(2019)12-1258-04
作者:
余子云1游 静1汤坤鑫1杨柳珍2黄志华薛进华陈 涛温二生
赣南医学院基础医学院 1.2016级本科生; 2.2017级本科生,江西 赣州 341000
Author(s):
YU Zi-yun1 YOU Jing1 TANG Kun-xin1 YANG Liu-zhen2 HUANG Zhi-hua XUE Jin-hua CHEN Tao WEN Er-sheng
of Grade 2016; 2.Undergraduate student of Grade 2017, Ganzhou, Jiangxi 341000
关键词:
帕金森病 神经退行性疾病 动物模型 细胞模型
Keywords:
Parkinson's disease neurodegenerative disease animal model cell model
分类号:
R742
DOI:
10.3969/j.issn.1001-5779.2019.12.018
文献标志码:
A
摘要:
帕金森病(Parkinson's Disease,PD)是一种神经退行性疾病,该病的主要临床特征为静止性震颤、动作迟缓及减少、肌张力增高、姿势不稳等。随着人们对帕金森病的深入了解,帕金森病的研究包括整体、器官和系统、细胞和分子乃至基因等水平。动物模型的制备对PD的研究具有举足轻重的作用,本文拟对近年来帕金森病的模型研究做一综述,以便为科学研究提供参考。
Abstract:
Parkinson's disease(PD)is a neurodegenerative disease, the main clinical features of which are static tremor, slow and decreased movement, muscle tension, posture instability. With the understanding of Parkinson's disease, the study of Parkinson's disease has been carried out to the levels of animals, cells, molecules and even genes. In this paper, the research of Parkinson's disease model is reviewed in order to provide reference for scientific research.

参考文献/References:

[1] Vingill S, Connor-Robson N, Wade-Martins R. Are rodent models of Parkinson's disease behaving as they should[J]. Behavioural Brain Research, 2018, 352(10):133-141.
[2] Goes A T R, Souza L C, Filho C B. Neuroprotective effects of swimming training in a mouse model of Parkinson's disease induced by 6-hydroxydopamine[J]. Neuroscience, 2014, 258(1):61-71.
[3] Cenci M A, Crossman A R. Animal models of l-dopa-induced dyskinesia in Parkinson's disease[J]. Movement Disorders, 2018, 33(3):1-11.
[4] Xian-Si Z, Wen-Shuo G, Jin-Jing J. Neurotoxin-Induced Animal Models of Parkinson Disease: Pathogenic Mechanism and Assessment[J]. ASN Neuro, 2018, 10(5):1-15.
[5] Dauer W, Przedborski S. Parkinson's Disease: Review Mechanisms and Models[J]. Neuron, 2003, 39(9):889-909.
[6] Renshi Xun, Yiyi Zhou, Xin Fang. The possible mechanism of Parkinson's diseaseprogressive damage and the preventive effect of GM1 in the rat model induced by 6-hydroxydopamine[J]. Beain Research, 2014, 1592(12):73-81.
[7] Hector Rosas-Hernandeza, Srinivasulu Chigurupatib James Raymicka. Identification of altered microRNAs in serum of a mouse model of Parkinson's disease[J]. Neuroscinece Letter, 2018,687(11):1-9.
[8] Alam G, Edler M, Burchfield S. Single Low Doses of MPTP Decrease Tyrosine Hydroxylase Expression in the Absence of Overt Neuron Loss[J]. Neurotoxicology, 2017,60(5):99-106.
[9] Vehovszky A, Henriette Szabó, László Hiripi. A possible model for Parkinson's disease in an invertebrate[J]. European Journal of euscience, 2010,25(7):2123-30.
[10] Morais, Lívia H, Lima M M S, et al. Characterization of motor, depressive-like and neurochemical alterations induced by a short-term rotenone administration[J]. Pharmacological Reports, 2012,64(5):1081-1090.
[11] Medeiros-Linard C F B, Andrade-Da-Costa B L D S, Augusto R L. Anacardic Acids from Cashew Nuts Prevent Behavioral Changes and Oxidative Stress Induced by Rotenone in a Rat Model of Parkinson's Disease[J]. Neurotoxicity Research, 2018, 34(2):250-262.
[12] Johnson M E, Stringer A, Bobrovskaya L. Rotenone induces gastrointestinal pathology and microbiota alterations in a rat model of Parkinson's disease[J]. Neurotoxicology, 2018,65(3):174-185.
[13] 郭涌斐,孙懿,赵欣.DJ-1蛋白对线粒体的功能调节在帕金森病中的作用[J].中国药理学通报,2016,32(1):22-26.
[14] Bonifati V, Rizzu P, van Baren M J. Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism[J]. Science, 2003,299(5604): 256-259.
[15] Wenjun Xiong, Jinghai Hua, Zuheng Liu. PTEN induced putative kinase 1(PINK1)alleviates angiotensin Ⅱ-induced cardiac injury by ameliorating mitochondrial dysfunction[J]. International Journal of Cardiology, 2018,(9): 198-205.
[16] Z Zha, J Wang, X Wang. Involvement of PINK1/Parkin-mediated mitophagy in AGE-induced cardiomyocyte aging[J]. Int J Cardiol, 2017,227(1):201-208.
[17] Vanessa A Morais, Dominik Haddad. PINK1 Loss-of-Function Mutations Affect Mitochondrial Complex I Activity via NdufA10 Ubiquinone Uncoupling[J]. Science, 2014,344(6180):203-207.
[18] Hao Deng, Lamei Yuan. Genetic variants and animal models in SNCA and Parkinson disease[J]. Ageing Research Reviews, 2014,15(1):161-176.
[19] Kirik D, Annett LE, Burger C. Nigrostriatal alpha-synucleinopathy induced by viral vector-mediated overexpression of human alpha-synuclein: a new primate model of Parkinson's disease[J]. Proc Natl Acad Sci USA, 2003,100(5): 2884-2889.
[20] Yacoubian T A, Cantuti-Castelvetri I, Bérengère Bouzou. Transcriptional dysregulation in a transgenic model of Parkinson disease[J]. Neurobiology of Disease, 2008,29(3):515-528.
[21] Sherer TB, Trimmer PA, Borland K. Chronic reduction in complex I function alters calcium signaling in SH-SY5Y neuroblastoma cells[J]. Brain Research, 2001,891(1-2):94-105.
[22] Zhang J Y, Deng Y N, Zhang M. SIRT3 Acts as a Neuroprotective Agent in Rotenone-Induced Parkinson Cell Mode[J]. Neurochem Res, 2016,47(7): 1761-1733.
[23] Xue-Li L, Wei-Dong C, Juan L. Protective effect of estrogen on apoptosis in a cell culture model of Parkinson's disease[J]. Toxicology, 2008, 31(5):258-264.

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备注/Memo

备注/Memo:
基金项目:国家创新创业训练项目(No.201810413009); 江西省教育厅项目(No.GJJ180814); 赣南医学院校级重点项目(No.ZD201807); 赣南医学院校级一般项目(No.YB201817); 赣南医学院本科生科技创新项目(No.XS201723)
通信作者:温二生,男,硕士,副教授,主要从事神经退行性疾病发病机制及药物干预研究。E-mail:wen90169@126.com
更新日期/Last Update: 2019-12-30