必须声明标量变量 "@Script_ID"。 食欲素系统在疼痛调制中作用的研究进展-《赣南医学院学报》

[1]胡帮胜,江连祥,戴泽平.食欲素系统在疼痛调制中作用的研究进展[J].赣南医学院学报,2019,39(12):1262-1265.[doi:10.3969/j.issn.1001-5779.2019.12.019]
 HU Bang-sheng,JIANG Lian-xiang,DAI Ze-ping.Advances in research on the role of Orexin system in pain modulation[J].,2019,39(12):1262-1265.[doi:10.3969/j.issn.1001-5779.2019.12.019]
点击复制

食欲素系统在疼痛调制中作用的研究进展()
分享到:

《赣南医学院学报》[ISSN:1001-5779/CN:36-1154/R]

卷:
39
期数:
2019年12期
页码:
1262-1265
栏目:
综述
出版日期:
2019-12-31

文章信息/Info

Title:
Advances in research on the role of Orexin system in pain modulation
文章编号:
1001-5779(2019)12-1262-04
作者:
胡帮胜1江连祥2戴泽平2
皖南医学院 1.2018级硕士研究生; 2.第一附属医院麻醉科,安徽 芜湖 241000
Author(s):
HU Bang-sheng1 JIANG Lian-xiang2 DAI Ze-ping2
Wannan Medical College 1.Postgraduate student, Grade 2018; 2.Department of Anesthesiology, the First Affiliated Hospital, Wuhu, Anhui 241000
关键词:
食欲素 疼痛 抗伤害
Keywords:
Orexin Pain Antinociception
分类号:
R441.1
DOI:
10.3969/j.issn.1001-5779.2019.12.019
文献标志码:
A
摘要:
食欲素(Orexin)是下丘脑神经元分泌的兴奋性神经肽,分为OrexinA和OrexinB两种分子亚型。随着对Orexin的研究深入,其生理功能逐渐被揭示,从最初的促进食欲、能量平衡、睡眠觉醒周期到调控学习记忆、心血管系统以及药物成瘾等。近年来研究发现,Orexin及其受体在疼痛调制中发挥着关键作用。认识和研究食欲素系统在不同类型疼痛中的调制作用,为临床治疗各种急慢性疼痛以及新型镇痛药物的开发提供新的靶点。
Abstract:
:Orexin is an excitatory neuropeptide secreted by hypothalamic neurons and is divided into two molecular subtypes, OrexinA and OrexinB. With the research on Orexin, its physiological functions are gradually revealed, from the initial promotion of appetite, energy balance, sleep awakening cycle to regulation of learning and memory, cardiovascular system and drug addiction. In recent years, studies have found that Orexin and its receptors play a key role in pain modulation. To understand and study the modulation of Orexin system in different types of pain, it provides a new target for clinical treatment of various acute and chronic pain and the development of new analgesic drugs.

参考文献/References:

[1] Sakurai T, Amemiya A, Ishii M, et al. Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior[J]. Cell, 1998,92(5):1-696.
[2] de Lecea L, Kilduff T S, Peyron C, et al. The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity[J]. Proc Natl Acad Sci U S A, 1998,95(1):322-327.
[3] Sakurai T. The neural circuit of orexin(hypocretin): maintaining sleep and wakefulness[J]. Nat Rev Neurosci, 2007,8(3):171-181.
[4] Tyree S M, Borniger J C, de Lecea L. Hypocretin as a Hub for Arousal and Motivation[J]. Front Neurol, 2018,9:413.
[5] Zhou J J, Yuan F, Zhang Y, et al. Upregulation of orexin receptor in paraventricular nucleus promotes sympathetic outflow in obese Zucker rats[J]. Neuropharmacology, 2015,99:481-490.
[6] Ran M, Wang Z, Yang H, et al. Orexin-1 receptor is involved in ageing-related delayed emergence from general anaesthesia in rats[J]. Br J Anaesth, 2018,121(5):1097-1104.
[7] Soya S, Shoji H, Hasegawa E, et al. Orexin receptor-1 in the locus coeruleus plays an important role in cue-dependent fear memory consolidation[J]. J Neurosci, 2013,33(36):14549-14557.
[8] Yin J, Mobarec J C, Kolb P, et al. Crystal structure of the human OX2 orexin receptor bound to the insomnia drug suvorexant[J]. Nature, 2015,519(7542):247-250.
[9] Langmead C J, Jerman J C, Brough S J, et al. Characterisation of the binding of [3H]-SB-674042, a novel nonpeptide antagonist, to the human orexin-1 receptor[J]. Br J Pharmacol, 2004,141(2):340-346.
[10] Date Y, Ueta Y, Yamashita H, et al. Orexins, orexigenic hypothalamic peptides, interact with autonomic, neuroendocrine and neuroregulatory systems[J]. Proc Natl Acad Sci U S A, 1999,96(2):748-753.
[11] Marcus J N, Aschkenasi C J, Lee C E, et al. Differential expression of orexin receptors 1 and 2 in the rat brain[J]. J Comp Neurol, 2001,435(1):6-25.
[12] Heidari-Oranjaghi N, Azhdari-Zarmehri H, Erami E, et al. Antagonism of orexin-1 receptors attenuates swim- and restraint stress-induced antinociceptive behaviors in formalin test[J]. Pharmacol Biochem Behav, 2012,103(2):299-307.
[13] Cady R J, Denson J E, Sullivan L Q, et al. Dual orexin receptor antagonist 12 inhibits expression of proteins in neurons and glia implicated in peripheral and central sensitization[J]. Neuroscience, 2014,269:79-92.
[14] Yazdi-Ravandi S, Razavi Y, Haghparast A, et al. Orexin A induced antinociception in the ventral tegmental area involves D1 and D2 receptors in the nucleus accumbens[J]. Pharmacol Biochem Behav, 2014,126:1-6.
[15] Mobarakeh J I, Takahashi K, Sakurada S, et al. Enhanced antinociception by intracerebroventricularly and intrathecally-administered orexin A and B(hypocretin-1 and -2)in mice[J]. Peptides, 2005,26(5):767-777.
[16] Emam A H, Hajesfandiari N, Shahidi S, et al. Modulation of nociception by medial pre-optic area orexin a receptors and its relation with morphine in male rats[J]. Brain Res Bull, 2016,127:141-147.
[17] Ozcan M, Ayar A, Serhatlioglu I, et al. Orexins activates protein kinase C-mediated Ca2+ signaling in isolated rat primary sensory neurons[J]. Physiol Res, 2010,59(2):255-262.
[18] Chiou L C, Lee H J, Ho Y C, et al. Orexins/hypocretins: pain regulation and cellular actions[J]. Curr Pharm Des, 2010,16(28):3089-3100.
[19] Holden J E, Wang E, Moes J R, et al. Differences in carbachol dose, pain condition, and sex following lateral hypothalamic stimulation[J]. Neuroscience, 2014,270:226-235.
[20] Wardach J, Wagner M, Jeong Y, et al. Lateral Hypothalamic Stimulation Reduces Hyperalgesia Through Spinally Descending Orexin-A Neurons in Neuropathic Pain[J]. West J Nurs Res, 2016,38(3):292-307.
[21] Jahangirvand M, Yazdi F, Moradi M, et al. Intra-accumbal Orexin-1 Receptors are Involved in Antinociception Induced by Stimulation of the Lateral Hypothalamus in the Formalin Test as an Animal Model of Persistent Inflammatory Pain[J]. Iran J Pharm Res, 2016,15(4):851-859.
[22] Okumura T, Nozu T, Kumei S, et al. Role of the cannabinoid signaling in the brain orexin- and ghrelin-induced visceral antinociception in conscious rats[J]. J Pharmacol Sci, 2018,137(2):230-232.
[23] Esmaeili M H, Reisi Z, Ezzatpanah S, et al. Role of orexin-2 and CB1 receptors within the periaqueductal gray matter in lateral hypothalamic-induced antinociception in rats[J]. Behav Pharmacol, 2017,28(1):83-89.
[24] Esmaeili M H, Reisi Z, Ezzatpanah S, et al. Functional interaction between orexin-1 and CB1 receptors in the periaqueductal gray matter during antinociception induced by chemical stimulation of the lateral hypothalamus in rats[J]. Eur J Pain, 2016,20(10):1753-1762.
[25] Toyama S, Shimoyama N, Shimoyama M. The analgesic effect of orexin-A in a murine model of chemotherapy-induced neuropathic pain[J]. Neuropeptides, 2017,61:95-100.
[26] Kooshki R, Abbasnejad M, Esmaeili-Mahani S, et al. The effect of CA1 administration of orexin-A on hippocampal expression of COX-2 and BDNF in a rat model of orofacial pain[J]. Arq Neuropsiquiatr, 2018,76(9):603-608.
[27] Bahaaddini M, Khatamsaz S, Esmaeili-Mahani S, et al. The role of trigeminal nucleus caudalis orexin 1 receptor in orofacial pain-induced anxiety in rat[J]. Neuroreport, 2016,27(15):1107-1113.
[28] Okumura T, Nozu T, Kumei S, et al. Antinociceptive action against colonic distension by brain orexin in conscious rats[J]. Brain Res, 2015,1598:12-17.
[29] Schurks M. Genetics of cluster headache[J]. Curr Pain Headache Rep, 2010,14(2):132-139.
[30] Barloese M, Jennum P, Lund N, et al. Reduced CSF hypocretin-1 levels are associated with cluster headache[J]. Cephalalgia, 2015,35(10):869-876.
[31] Roohbakhsh A, Alavi M S, Azhdari-Zarmehri H. The Orexinergic(Hypocretin)System and Nociception: An Update to Supraspinal Mechanisms[J]. Curr Med Chem, 2018,25(32):3917-3929.
[32] Zhou W, Cheung K, Kyu S, et al. Activation of orexin system facilitates anesthesia emergence and pain control[J]. Proc Natl Acad Sci U S A, 2018,115(45):E10740-E10747.

相似文献/References:

[1]王林平.长效镇痛剂联合耳穴压丸法治疗肛肠病术后疼痛的效果分析[J].赣南医学院学报,2018,38(04):381.[doi:10.3969/j.issn.1001-5779.2018.04.020]
 WANG Lin-ping.Effect Analysis of Long-acting Analgesic Combined with Auricular Point Pressing Pill on Postoperative Pain of Anorectal Disease[J].,2018,38(12):381.[doi:10.3969/j.issn.1001-5779.2018.04.020]
[2]陈健华,隗洪进,李栩萍,等.罗哌卡因防治经脐单孔腹腔镜手术后疼痛的临床观察[J].赣南医学院学报,2018,38(05):468.[doi:10.3969/j.issn.1001-5779.2018.05.014]
 CHEN Jian-hua,KUI Hong-jin,LI Xu-ping,et al.Clinical observation of ropivacaine for prevention and treatment of postoperative pain after transumbilical single port laparoscopic surgery[J].,2018,38(12):468.[doi:10.3969/j.issn.1001-5779.2018.05.014]
[3]黄 媚.术中舒适护理对人工膝关节置换术患者术后疼痛及膝关节功能的影响[J].赣南医学院学报,2018,38(05):498.[doi:10.3969/j.issn.1001-5779.2018.05.023]
[4]刘 璇,吴丽萍,陈睿云,等.音乐疗法对术后患者疼痛和生理状态影响的Meta分析[J].赣南医学院学报,2018,38(08):806.[doi:10.3969/j.issn.1001-5779.2018.08.020]
 LIU Xuan,WU Li-ping,CHEN Rui-yun,et al.The effects of music therapy on postopeative pain and vital signs following surgery a Metaanalysis[J].,2018,38(12):806.[doi:10.3969/j.issn.1001-5779.2018.08.020]
[5]李秀文,龙朝庆.自制鼓膜穿刺器对减轻耳内镜下鼓膜穿刺术中患者疼痛程度的效果观察[J].赣南医学院学报,2019,39(08):812.[doi:10.3969/j.issn.1001-5779.2019.08.015]
 LI Xiu-wen,LONG Chao-qing.Effect of self-made tympanic membrane puncture apparatus on alleviating pain in patients undergoing auricular endoscopic tympanum puncture[J].,2019,39(12):812.[doi:10.3969/j.issn.1001-5779.2019.08.015]
[6]黎裕星,黎铨初,李其金,等.超声引导下臂丛神经阻滞联合喉罩全麻在肩关节镜手术的应用[J].赣南医学院学报,2019,39(09):903.[doi:10.3969/j.issn.1001-5779.2019.09.009]
 LI Yu-xing,LI Quan-chu,LI Qi-jin,et al.Application of brachial plexus block combined with laryngeal mask general anesthesia under ultrasound guidance in shoulder arthroscopic surgery[J].,2019,39(12):903.[doi:10.3969/j.issn.1001-5779.2019.09.009]

备注/Memo

备注/Memo:
基金项目:2018年皖南医学院中青年科研基金项目(编号:WK2018F17)
通信作者:戴泽平,男,博士,主任医师,教授,研究方向:麻醉与脑。E-mail:zpdai@wnmc.edu.cn
更新日期/Last Update: 2019-12-30