必须声明标量变量 "@Script_ID"。 早卵泡期长效长方案与拮抗剂方案在卵巢正常反应人群中的应用比较-《赣南医学院学报》

[1]帅 妹,伍琼芳.早卵泡期长效长方案与拮抗剂方案在卵巢正常反应人群中的应用比较[J].赣南医学院学报,2020,40(06):554-557.[doi:10.3969/j.issn.1001-5779.2020.06.004]
 SHUAI Mei,WU Qiong-fang.Comparison of the early follicular phase prolonged protocol and GnRH antagonist protocol in patients with normal ovarian response[J].,2020,40(06):554-557.[doi:10.3969/j.issn.1001-5779.2020.06.004]
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早卵泡期长效长方案与拮抗剂方案在卵巢正常反应人群中的应用比较()
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《赣南医学院学报》[ISSN:1001-5779/CN:36-1154/R]

卷:
40
期数:
2020年06期
页码:
554-557
栏目:
临床研究
出版日期:
2020-07-22

文章信息/Info

Title:
Comparison of the early follicular phase prolonged protocol and GnRH antagonist protocol in patients with normal ovarian response
文章编号:
1001-5779(2020)06-0554-04
作者:
帅 妹1伍琼芳2
1.赣州市妇幼保健院生殖与遗传科,江西 赣州 341000; 2.江西省妇幼保健院,江西 南昌 330000
Author(s):
SHUAI Mei1 WU Qiong-fang2
1.Department of Reproduction and Genetics, Ganzhou Maternal and Child Health Hospital, Ganzhou, Jiangxi 341000; 2.Jiangxi Maternal and Child Health Hospital, Nanchang, Jiangxi 330000
关键词:
早卵泡期长效长方案 拮抗剂方案 正常反应
Keywords:
The early follicular phase prolonged protocol GnRH antagonist Normal ovarian response populations
分类号:
R711.6
DOI:
10.3969/j.issn.1001-5779.2020.06.004
文献标志码:
A
摘要:
目的:探讨早卵泡期长效长方案与拮抗剂方案在卵巢正常反应人群中应用疗效。方法:将2018年10月-2019年10月收治的卵巢正常反应试管助孕患者200例,早卵泡期长效长方案(A组)100例及拮抗剂方案(B组)100例。比较两组激素水平、胚胎情况、妊娠结局及OHSS发生率。结果:卵巢正常反应第一次行IVF/ICSI-ET助孕患者200个周期纳入本研究。两组患者年龄、体重指数(BMI)、AMH、基础卵泡数(AFC)差异无统计学意义(P>0.05); 两组2PN受精率、优胚率、移植率、种植率及早期流产率差异无统计学意义(P>0.05); HCG日P两组差异无统计学意义(P>0.05)。早卵泡期长效长方案组HCG日E2、促排天数、GN用量及获卵数显著高于拮抗剂组(P<0.05); HCG日LH显著低于拮抗剂组(P<0.05); 早卵泡期长效长方案组种植率及新鲜移植周期临床妊娠率高于拮抗剂方案组(P<0.05),虽OHSS发生率高于拮抗剂组,但两组差异无统计学意义(P>0.05)。结论:正常反应患者应用早卵泡期长效长方案较拮抗剂方案获卵数增加,可提高新鲜移植临床妊娠率,但是OHSS风险有增高趋势。当基础窦卵泡大小均匀时可选择拮抗剂方案,拮抗剂方案可缩短治疗周期时间。
Abstract:
Objective: To investigate the effect of the early follicular phase prolonged protocol and GnRH antagonist in patients with normal ovarian response. Methods: 200 cases of ovarian normal response test tube assisted pregnancy who were treated from October 2018 to October 2019 were divided into two groups: 100 cases in the long-acting long-term regimen of early follicular phase and 100 cases in the antagonist-mode group. Hormone levels, embryo status, pregnancy outcome, and OHSS incidence were compared between the two groups. Results: There was no significant difference in age, body mass index(BMI), AMH, and basal follicle number(AFC)between the two groups(P>0.05); There were no significant differences in the rate of 2PN fertilization, the rate of superior embryos, the rate of transplantation, and the early abortion rate between the two groups(P>0.05); There was no significant difference between the two groups on HCG day(P>0.05). In the early-follicle long-acting long-term regimen group, the HCG day E2, the number of days to promote excretion, the amount of GN,and the number of eggs obtained were significantly higher than those in the antagonist group(P<0.05); LH on HCG day was significantly lower than the antagonist group(P<0.05); The pregnancy rate of fresh transplantation in the early-follicle long-acting long-term regimen was higher than that in the antagonist regimen(P<0.05); Although the incidence of OHSS was higher than GnRH antagonist group, there was no significant difference between the two groups(P>0.05). Conclusions: Application of the early follicular phase prolonged protocol in patients with normal response can improve clinical pregnancy rate of fresh transplantation compared with antagonist; OHSS risk tends to increase. GnRH antagonist shorten treatment cycle time and reduce patient costs. When the basal follicles are homogeneous, the choice of GnRH antagonist and the choice of blastocysts may also improve clinical outcomes.

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备注/Memo

备注/Memo:
作者简介:帅妹,女,在读研究生,主治医师,研究方向:生殖医学。E-mail:178230731@qq.com
更新日期/Last Update: 2020-07-30