必须声明标量变量 "@Script_ID"。 实验小鼠阴道膈及阴道闭锁的研究进展-《赣南医学院学报》

[1]李增民,徐 鹰,管观文,等.实验小鼠阴道膈及阴道闭锁的研究进展[J].赣南医学院学报,2020,40(06):604-610.[doi:10.3969/j.issn.1001-5779.2020.06.015]
 LI Zeng-min,XU Ying,GUAN Guan-wen,et al.Research summary of formation mechanism on vaginal septum and atresia in mouse[J].,2020,40(06):604-610.[doi:10.3969/j.issn.1001-5779.2020.06.015]





Research summary of formation mechanism on vaginal septum and atresia in mouse
李增民12徐 鹰1管观文1蔡茜茜1江伟华1任 震1唐建红1
1.赣南医学院 赣州市实验动物工程技术研究中心,江西 赣州 341000; 2.江西农业大学 江西省动物营养重点实验室,江西 南昌 330000
LI Zeng-min12 XU Ying1 GUAN Guan-wen1 CAI Xi-xi1 JIANG Wei-hua1 REN Zhen1 TANG Jian-hong1
1.Laboratory Animal Engineering Research Center of Ganzhou, Gannan Medical University, Ganzhou, Jiangxi 341000; 2.Key Laboratory of Animal Nutrition of Jiangxi, Jiangxi Agricultural University, Nanchang, Jiangxi 330000
小鼠 阴道膈 阴道闭锁 形成机制
Mouse Vaginal septum Vaginal atresia Formation mechanism
Vaginal septum and atresia are rare diseases in mammals' reproductive system. It is hardly to reach a consensus on the formation mechanism due to the lack of systematic review on the limited article about these two defects. In this paper, the researching method, trend and the progress of the vaginal septum and atresia in mouse was briefly reviewed, with the hope to provide references for laboratory animals, medicine and veterinary researchers.


[1] 陈春. 阴道斜隔综合征的临床及分子遗传学研究[D].北京:协和医学院,2016.
[2] 李蕾, 朱兰. Wnt信号通路在女性下生殖道发育异常中的研究进展[J].现代妇产科进展, 2017, 26(12):261-263.
[3] 陈娜, 朱兰, 冷金花,等. 阴道闭锁的特点和处理[J].中国计划生育和妇产科, 2017, 9(9):3-4.
[4] 朱松楠. 阴道斜隔综合征的诊断与治疗[J].国际妇产科学杂志, 2017, 44(3):262-264.
[5] 王轶男, 朱兰. 女性生殖道发育异常分类介绍[J].实用妇产科杂志, 2015,31(2):81-83.
[6] NOMURA K, KOREEDA T, KAWATA M, et al. Vaginal atresia with transverse septum in a cat[J]. Journal of Veterinary Medical Science, 1997, 59(11):1045.
[7] LEZMI S, THIBAULT-DUPREY K, BIDAUT A, et al. Spontaneous metritis related to the presence of vaginal septum in pregnant Sprague Dawley Crl:CD(SD)rats: impact on reproductive toxicity studies[J]. Veterinary Pathology, 2011, 48(5):964-969.
[8] LENARTOWICZ M, BRZEK B, POLANSKI Z, et al. Changes in germ cells population and in vitro oocyte maturation in female mice with imperforated vagina[J]. Journal of Experimental Zoology Part A Ecological Genetics & Physiology, 2010, 309A(5):269-277.
[9] MURATA T, ISHITSUKA Y, KAROUJI K, et al. β-cateninC429S mice exhibit sterility consequent to spatiotemporally sustained Wnt signalling in the internal genitalia[J]. Scientific Reports, 2015, 4(1):6959.
[10] ZHAO F, ZHOU J, LI R, et al. Novel function of LHFPL2 in female and male distal reproductive tract development[J]. Scientific Reports, 2016, 6:23037.
[11] WU H, TANG H, CHEN Y, et al. High incidence of distal vaginal atresia in mice lacking Tyro3 RTK subfamily[J]. Molecular Reproduction & Development, 2010, 75(12):1775-1782.
[12] GEARHART S, KALISHMAN J, MELIKYAN H, et al. Increased incidence of vaginal septum in C57BL/6J mice since 1976[J]. Comparative Medicine, 2004, 54(4):418-421.
[13] CHANG T K, HO P, LIANG C T, et al. Effects of vaginal septa on the reproductive performance of BALB/cByJNarl mice[J]. Journal of the American Association for Laboratory Animal Science, 2013, 52(5):520-523.
[14] GINTY I, HOOGSTRATEN-MILLER S. Perineal swelling in a mouse[J]. Laboratory Animal, 2008, 37(5):196-196.
[15] GOWEN J W, HEIDENTHAL G. Imperforate in the mouse, its inheritance and relation to endocrine function[J]. Journal of Experimental Zoology Part A Ecological Genetics & Physiology, 2010, 89(3):433-450.
[16] OROFINO A, LANZILLOTTO M P, SAVINO C L, et al. Acute abdominal pain in an adolescent female with Herlyn-Werner-Wunderlich syndrome and hemicervicovaginal atresia[J]. Journal of Pediatric Surgery Case Reports, 2018, 31:17-19.
[17] ATACA D, CAIKOVSKI M, PIERSIGILLI A, et al. Adamts18, deletion results in distinct developmental defects and provides a model for congenital disorders of lens, lung, and female reproductive tract development[J]. Biology Open, 2016, 5(11):1585-1594.
[18] LINDSTEN T, ROSS A J, KING A, et al. The combined functions of proapoptotic Bcl-2 family members Bak and Bax are essential for normal development of multiple tissues[J]. Molecular Cell, 2001, 6(6):1389-1399.
[19] HAMMES A, ANDREASSEN T K, SPOELGEN R, et al. Role of endocytosis in cellular uptake of sex steroids[J]. Cell, 2005, 122(5): 751-762.
[20] MITTAG J, WINTERHAGER E, BAUER K, et al. Congenital hypothyroid female Pax8-deficient mice are infertile despite thyroid hormone replacement therapy[J]. Endocrinology, 2007, 148(2):719-725.
[21] WARR N, BOGANI D, SIGGERS P, et al. Minor abnormalities of Testis development in mice lacking the gene encoding the MAPK signalling component, MAP3K1[J]. PLOS ONE, 2011, 6(5):e19572.
[22] RODRIGUEZ I, ARAKIA K, KHATIB K, et al. Mouse vaginal opening is an apoptosis-dependent process which can be prevented by the overexpression of Bcl2[J]. Developmental Biology, 1997, 184(1):115-121.
[23] REN D, TU H C, KIM H, et al. BID, BIM, and PUMA are essential for activation of the BAX- and BAK-dependent cell death program[J]. Science, 2010, 330(6009):1390-1393.
[24] INCE T A, CVIKO A P, QUADE B J, et al. P63 coordinates anogenital modeling and epithelial cell differentiation in the developing female urogenital tract[J]. American Journal of Pathology, 2002, 161(4):1111-1117.
[25] VANDENBERG A L, SASSOON D A. Non-canonical Wnt signaling regulates cell polarity in female reproductive tract development via van gogh-like 2[J]. Development, 2009, 136(9):1559-1570.
[26] 王君, 刘光新, 孔佳,等. 腹腔镜辅助生物补片人工阴道成形联合宫颈阴道接通术治疗Ⅱ型阴道闭锁1例报告[J].中国微创外科杂志, 2016, 16(1):72-74.
[27] 李靓, 张晓平, 谢志红, 等. 部分小阴唇皮瓣网状移植人工阴道成形术治疗先天性阴道闭锁或先天性无阴道9例[J].蚌埠医学院学报, 2019, 44(2):199-201.
[28] 罗光楠, 潘宏信. 罗湖术式在阴道闭锁治疗中的应用及热点问题探讨[J].国际妇产科学杂志, 2017, 44(3):245-247.


 XU Yan,ZENG Yong,CHEN Yu-yao.Effects of 3-month Freely Drink with 10% Alcohol on Mouse Livers[J].,2016,36(06):362.[doi:10.3969/j.issn.1001-5779.2016.03.008]


基金项目:赣南医学院校级课题(YB201822; ZD201822); 赣南医学院博士启动金项目(QD201802)
更新日期/Last Update: 2020-07-30