必须声明标量变量 "@Script_ID"。 新生儿坏死性小肠结肠炎的发病机制及防治进展-《赣南医学院学报》

[1]冉 云,文剑波.新生儿坏死性小肠结肠炎的发病机制及防治进展[J].赣南医学院学报,2020,40(06):611-615.[doi:10.3969/j.issn.1001-5779.2020.06.016]
 RAN Yun,WEN Jian-bo.Progress in pathogenesis, prevention and treatment of neonatal necrotizing enterocolitis[J].,2020,40(06):611-615.[doi:10.3969/j.issn.1001-5779.2020.06.016]
点击复制

新生儿坏死性小肠结肠炎的发病机制及防治进展()
分享到:

《赣南医学院学报》[ISSN:1001-5779/CN:36-1154/R]

卷:
40
期数:
2020年06期
页码:
611-615
栏目:
综述
出版日期:
2020-07-22

文章信息/Info

Title:
Progress in pathogenesis, prevention and treatment of neonatal necrotizing enterocolitis
文章编号:
1001-5779(2020)06-0611-05
作者:
冉 云1文剑波2
赣南医学院 1.2018 级硕士研究生,江西 赣州 341000; 2.第六临床医学院,江西 萍乡 337000
Author(s):
RAN Yun1 WEN Jian-bo2
Gannan Medical University 1.Postgraduate student, Grade 2018, Ganzhou, Jiangxi 341000; 2.The Sixth Affiliated Hospital, Pingxiang, Jiangxi 337000
关键词:
坏死性小肠结肠炎 发病机制 预防 治疗 新生儿
Keywords:
Necrotizing enterocolitis Pathogenesis Prevention Treatment Neonate
分类号:
R574
DOI:
10.3969/j.issn.1001-5779.2020.06.016
文献标志码:
A
摘要:
坏死性小肠结肠炎(NEC)是新生儿,特别是早产儿中较为常见的肠道炎症性疾病。新生儿NEC死亡率高,并发症较多,严重者会导致新生儿全身各器官的功能受损,并影响其生长发育。尽管NEC首次报道距今已有近百年历史,但对于其确切机制尚不清楚,防治策略也尚未形成统一标准。本文主要从近年来NEC的发病机制以及防治策略等方面作一综述,并展望可能改善NEC治疗效果的新方法。
Abstract:
Necrotizing enterocolitis(NEC)is a more common intestinal inflammatory disease in newborns, especially in preterm infants. The neonatal NEC has a high mortality rate and more complications, and the severe cases will lead to the impairment of the function of the whole body organs of the newborn and affect its growth and development. Although it has a history of more than 100 years since its discovery, its exact mechanism is unclear and its prevention strategy has not yet formed a uniform standard.This article reviews the pathogenesis and prevention strategies of NEC in recent years, and looks forward to new methods to improve the therapeutic effect of NEC.

参考文献/References:

[1] JOSEF N, W A W. Necrotizing enterocolitis[J]. N Engl J Med, 2011,364(3):255-264.
[2] BELLODAS SANCHEZ J, KADROFSKE M. Necrotizing enterocolitis[J]. Neurogastroenterology & Motility, 2019,31(3):599-603.
[3] XIAOMEI L, XIAOWEN L, QINGJUAN S, et al. Fecal microbiota transplantation(FMT)could reverse the severity of experimental necrotizing enterocolitis(NEC)via oxidative stress modulation[J]. Free Radic Biol Med, 2017,108:32-43.
[4] KEWEI W, GUOZHONG T, KARL G S. Recent Advances in Prevention and Therapies for Clinical or Experimental Necrotizing Enterocolitis[J]. Dig Dis Sci, 2019,64(11):214-220.
[5] RAHUL J A, CYNTHIA L L, KEVIN P M, et al. The role of the intestinal barrier in the pathogenesis of necrotizing enterocolitis[J]. Shock, 2007,27(2):518-564.
[6] AXEL O, EWA H, YANG C, et al. Stereotypic Immune System Development in Newborn Children[J]. Cell, 2018,174(5):1023-1028.
[7] STEVEN C G, CHHINDER P S, WARD M R, et al. Reciprocal expression and signaling of TLR4 and TLR9 in the pathogenesis and treatment of necrotizing enterocolitis[J]. J Immunol, 2009,182(1):79-86.
[8] YIN P, XIAOYA D, XUELI X, et al. Monocyte activation and inflammation can exacerbate Treg/Th17 imbalance in infants with neonatal necrotizing enterocolitis[J]. Int Immunopharmacol, 2018,59:356-370.
[9] REBECCA E M, STEVEN D T. Temporal development of the infant gut microbiome[J]. Open Biol, 2019,9(9):108-114.
[10] MOHAN P, JULIA C, PHILLIP I T, et al. Intestinal dysbiosis in preterm infants preceding necrotizing enterocolitis: a systematic review and meta-analysis[J]. Microbiome, 2017,5(1):1179-1186.
[11] JESSICA R W, HUIYU G, BROCK P, et al. Paneth-cell-disruption-induced necrotizing enterocolitis in mice requires live bacteria and occurs independently of TLR4 signaling[J]. Dis Model Mech, 2017,10(6):1340-1347.
[12] MICHAEL J M, VALERIY P, MICHAEL C, et al. Redefining the role of intestinal microbes in the pathogenesis of necrotizing enterocolitis[J]. Pediatrics, 2010,125(4):79-86.
[13] STEPHEN M C, MICHAEL S, PREMYSL B. The interplay between the intestinal microbiota and the brain[J]. Nat Rev Microbiol, 2012,10(11):275-283.
[14] KRISTIN K, RUURD M V E, FRANK V B, et al. Impact of nutrition on brain development and its neuroprotective implications following preterm birth[J]. Pediatr Res, 2015,77(1-2):45-49.
[15] KENNETH H, KATHERINE C. An exclusively human milk diet reduces necrotizing enterocolitis[J]. Breastfeed Med, 2014,9(4):168-173.
[16] WILLEMIJN E C, STEFANIE M P K, MUIRNE C P, et al. Intake of own mother's milk during the first days of life is associated with decreased morbidity and mortality in very low birth weight infants during the first 60 days of life[J]. Neonatology, 2012,102(4):234-239.
[17] ALEXANDER H P, ANGELINA E A, JAMES W S, et al. Digested formula but not digested fresh human milk causes death of intestinal cells in vitro: implications for necrotizing enterocolitis[J]. Pediatr Res, 2012,72(6):356-367.
[18] MEGHAN B A, THEODORE K, HEATHER M, et al. Gut microbiota of healthy Canadian infants: profiles by mode of delivery and infant diet at 4 months[J]. CMAJ, 2013,185(5):1107-1115.
[19] RONNIE G, BARBARA J S, C M C, et al. Association of H2-blocker therapy and higher incidence of necrotizing enterocolitis in very low birth weight infants[J]. Pediatrics, 2006,117(2):91-97.
[20] RAEGAN W G, LYNN T, JOHANA N, et al. Histamine-2 receptor blockers alter the fecal microbiota in premature infants[J]. J Pediatr Gastroenterol Nutr, 2013,56(4):286-289.
[21] VENKATA S K, JAREEN M, ARDYTHE L M, et al. Prolonged initial empirical antibiotic treatment is associated with adverse outcomes in premature infants[J]. J Pediatr, 2011,159(5):1471-1475.
[22] MAJD D, STEVEN R G, ALEX G, et al. The impact of postnatal antibiotics on the preterm intestinal microbiome[J]. Pediatr Res, 2014,76(2):119-124.
[23] R C, P R, S L, et al. A retrospective analysis of the effect of human milk on prevention of necrotizing enterocolitis and postnatal growth[J]. J Perinatol, 2016,36(3):303-309.
[24] SANKET D S, NARENDRA D, TAMEKIA L J, et al. Early versus Delayed Human Milk Fortification in Very Low Birth Weight Infants-A Randomized Controlled Trial[J]. J Pediatr, 2016,174:55-59.
[25] WILLEMIJN E C, MARITA D W, VIOLA C, et al. Effect of Donor Milk on Severe Infections and Mortality in Very Low-Birth-Weight Infants: The Early Nutrition Study Randomized Clinical Trial[J]. JAMA Pediatr, 2016,170(7):66-70.
[26] ALONA B, RUBEN B, MICHAEL W, et al. Oral probiotics prevent necrotizing enterocolitis in very low birth weight neonates[J]. J Pediatr, 2005,147(2):234-239.
[27] DILEK D, BANU A, NURDAN D F, et al. The propre-save study: effects of probiotics and prebiotics alone or combined on necrotizing enterocolitis in very low birth weight infants[J]. J Pediatr, 2015,166(3):87-93.
[28] WANG Z, LIU L, HU X, et al. Probiotics may not prevent the deterioration of necrotizing enterocolitis from stage Ⅰ to Ⅱ/Ⅲ[J]. BMC Pediatrics, 2019,19(1):185.
[29] MICHAEL L J, THOMAS T, MALENE S C, et al. Antibiotics modulate intestinal immunity and prevent necrotizing enterocolitis in preterm neonatal piglets[J]. Am J Physiol Gastrointest Liver Physiol, 2014,306(1):141-144.
[30] BIRCK M, NGUYEN D N, CILIEBORG M, et al. Enteral but not parenteral antibiotics enhance gut function and prevent necrotizing enterocolitis in formula-fed newborn preterm pigs[J]. AJP Gastrointestinal and Liver Physiology, 2015,310:450-457.
[31] DHARMESH S, JOHN K H S. Antibiotic regimens for the empirical treatment of newborn infants with necrotising enterocolitis[J]. Cochrane Database Syst Rev, 2012(8):890-894.
[32] YIN Z, YIBO L, BIN Z, et al. Inflammation and Apoptosis: Dual Mediator Role for Toll-like Receptor 4 in the Development of Necrotizing Enterocolitis[J]. Inflamm Bowel Dis, 2017,23(1):785-789.
[33] KEZHEN H, SUBHAJIT M, VERA D, et al. Targeting the PXR-TLR4 signaling pathway to reduce intestinal inflammation in an experimental model of necrotizing enterocolitis[J]. Pediatr Res, 2018,83(5):147-152.
[34] YU H, XIN L, YUEJU Z. IRAK Inhibitor Protects the Intestinal Tract of Necrotizing Enterocolitis by Inhibiting the Toll-Like Receptor(TLR)Inflammatory Signaling Pathway in Rats[J]. Med Sci Monit, 2018,24:136-139.
[35] F T, G-R L, N L, et al. Insulin-like growth factor I reduces the occurrence of necrotizing enterocolitis by reducing inflammatory response and protecting intestinal mucosal barrier in neonatal rats model[J]. Eur Rev Med Pharmacol Sci, 2017,21(20):4711-4719.
[36] THOMAS J B, GUY D E, ROBERT L C. Fecal microbiota transplantation as a new therapy: from Clostridioides difficile infection to inflammatory bowel disease, irritable bowel syndrome, and colon cancer[J]. Curr Opin Pharmacol, 2019,49:1123-1129.
[37] CHRISTIAN P, MONIQUE M, PRICILA Á, et al. The protective effects of fecal microbiota transplantation in an experimental model of necrotizing enterocolitis[J]. J Pediatr Surg, 2019,54(8):157-163.
[38] ROBINSON J R, RELLINGER E J, HATCH L D, et al. Surgical necrotizing enterocolitis[J]. Seminars in Perinatology, 2017,41(1):70-79.
[39] CLARE M R, SIMON E, EDWARD M K, et al. Peritoneal drainage or laparotomy for neonatal bowel perforation? A randomized controlled trial[J]. Ann Surg, 2008,248(1):23-26.
[40] BENJAMIN D C, SAMIR K G. Does Surgical Management Alter Outcome in Necrotizing Enterocolitis?[J]. Clin Perinatol, 2019,46(1):876-880.

相似文献/References:

[1]江 茜,欧阳娟,黄 诚.神经病理性痛的发病机制及治疗研究[J].赣南医学院学报,2016,36(04):500.[doi:10.3969/j.issn.1001-5779.2016.04.001]
[2]尹 宝,曹 思,陈 涛,等.压力超负荷性心肌肥厚的现代研究进展[J].赣南医学院学报,2017,37(02):331.[doi:10.3969/j.issn.1001-5779.2017.02.047]
 YIN Bao,CAO Si,CHEN Tao,et al.Modern Research Progress of Pressure Overload-induced Cardiac Hypertrophy[J].,2017,37(06):331.[doi:10.3969/j.issn.1001-5779.2017.02.047]
[3]肖 坤,谢东明.心肌肥厚的发病机制与治疗现状[J].赣南医学院学报,2017,37(03):495.[doi:10.3969/j.issn.1001-5779.2017.03.049]
[4]游 静,顾乔乔,余子云,等.帕金森病发病机制的研究进展[J].赣南医学院学报,2019,39(07):733.[doi:10.3969/j.issn.1001-5779.2019.07.022]
 YOU Jing,GU Qiao-qiao,YU Zi-yun,et al.Research progress on pathogenesis of Parkinson's disease[J].,2019,39(06):733.[doi:10.3969/j.issn.1001-5779.2019.07.022]
[5]王东泰,谢家和,谢东明.运动预适应对尿毒症心肌病发挥保护作用的研究进展[J].赣南医学院学报,2020,40(02):158.[doi:10.3969/j.issn.1001-5779.2020.02.011]
 WANG Dong-tai,XIE Jia-he,XIE Dong-ming.Research progress on the protective effect of exercise preconditioning on uremia cardiomyopathy[J].,2020,40(06):158.[doi:10.3969/j.issn.1001-5779.2020.02.011]
[6]刘金平,黄海金,陈 枫,等.小儿淋巴管畸形诊治进展[J].赣南医学院学报,2020,40(02):206.[doi:10.3969/j.issn.1001-5779.2020.02.021]
 LIU Jin-ping,HUANG Hai-jin,CHEN Feng,et al.Progress in diagnosis and treatment of lymphatic malformation in children[J].,2020,40(06):206.[doi:10.3969/j.issn.1001-5779.2020.02.021]
[7]曾 勇,谢明峰,方 涛,等.婴幼儿血管瘤发病机制的研究进展[J].赣南医学院学报,2020,40(04):422.[doi:10.3969/j.issn.1001-5779.2020.04.022]
 ZENG Yong,XIE Ming-feng,FANG Tao,et al.Advances in the pathogenesis of infantile hemangiomas[J].,2020,40(06):422.[doi:10.3969/j.issn.1001-5779.2020.04.022]

备注/Memo

备注/Memo:
通信作者:文剑波,男,本科,教授,主任医师,研究方向:肠道微生态与肠道疾病关系。E-mail:wenjbpx@126.com
更新日期/Last Update: 2020-07-30